The accident happened shortly after 5 PM on lanes Mill Road.
One patient was heavily entrapped and needed to be extricated from the vehicle.
The extricated patient was transported to Ocean Medical Center in Brick with CPR in progress. He was pronounced dead at the hospital, police say.
The area will be shut down for a police investigation.
BREAKING UPDATE: Sources tell TLS this was the result of a road rage incident which possibly spilled over from the GSP. The victim was reportedly an innocent driver.