What happens if the person you sent Mishloach Manos to is dead drunk, are you yotzei? Rav Menashe Klein (Mishneh Halachos (4:91) says probably not. Halachicly, someone who has reached the level of intoxication of Lot is like a Shoteh and Patur from Mitzvos. He reasons that the Mitzva of Mishloach Manos depends on the status of the recipient and not the sender. If so, you have sent to someone who is Patur from the Mitzva and therefore you are not Yotzei. However, if he has time to sober up before Purim is over, then you are Yotzei.

Rav Menashe Klein distinguishes this from a case where the recipient is merely sleeping. In that case he believes you are probably Yotzei because another person can be Koneh for him, whereas a drunkard has has no way to be koneh anything. Revach.