The two-vehicle collision occurred at the intersection of Vermont Avenue and Locust Street shortly before 1 PM.
The driver of the pickup truck, as well as one student on board the bus were injured, officials say.
The driver was transported by EMS to Jersey Shore University Medical Center, and the student, said to be a teen, was transported by Lakewood First Aid to Monmouth Medical Center Southern Campus. The extent of injuries were not available.
The school bus, severely damaged in the crash, belonged to the Board of Education.